6 7 Because low HRV has been reported in patients with diabetes, hypertensive cardiac hypertrophy, and atherosclerosis, 1 8 9 prevalent disease may account for these findings. 3 Also, in the general population, low HRV is associated with death 4 5 and with the risk of cardiac events. In more recent years, low HRV has been shown to have prognostic value in patients with myocardial infarction. 1 2 The lack of HRV has long been used for the diagnosis of diabetic neuropathy. Therefore, HRV is considered a noninvasive marker of autonomic nervous system function. Heart rate variability (HRV) decreases under situations of stress, either emotional or physical, whereas it increases with rest. The heart rate of healthy persons displays beat-to-beat variations that result from fluctuations in autonomic nervous system activity at the sinus node. It is hypothesized that low HRV is a marker of less favorable health. The increased risk of death could not be attributed to a specific cause and could not be explained by other risk factors.Ĭonclusions-Low HRV was associated with increased risk of CHD and death from several causes. Subjects with low HRV had an adverse cardiovascular risk profile and an elevated risk of incident CHD and death. Relative rates of incident CHD and cause-specific death in tertiles of HRV were computed with Poisson regression for the case-cohort design. Time-domain measures of HRV were determined in a random sample of 900 subjects, for all subjects with incident CHD (395 subjects), and for all deaths (443 subjects) that occurred through 1993. At baseline, in 1987 to 1989, 2-minute rhythm strips were recorded. Methods and Results-We studied the predictive value of HRV for CHD and death from several causes in a population study of 14 672 men and women without CHD, aged 45 to 65, by using the case-cohort design. Customer Service and Ordering Informationīackground-Low heart rate variability (HRV) is associated with a higher risk of death in patients with heart disease and in elderly subjects and with a higher incidence of coronary heart disease (CHD) in the general population.Stroke: Vascular and Interventional Neurology.Journal of the American Heart Association (JAHA).Circ: Cardiovascular Quality & Outcomes.Arteriosclerosis, Thrombosis, and Vascular Biology (ATVB).
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